Developmental Dyslexia: Early Precursors, Neurobehavioral Markers, and Biological Substrates

Volume Editors: April A. Benasich Ph.D., R. Holly Fitch Ph.D.

Format: Hardcover, 376 pages, 6.0 x 9.0
ISBN: 9781598571868
Price: $74.95

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Understanding the precursors and early indicators of dyslexia is key to early identification and effective intervention. Now there's a single research volume that brings together the very latest knowledge on the earliest stages of dyslexia and the diverse genetic, neurobiological, and cognitive factors that may contribute to it. Based on findings first reported at the Dyslexia Foundation's 12th Extraordinary Brain Symposium, this landmark volume collects cutting-edge dyslexia research from the worlds foremost experts on this complex disorder, as well as insights from experts newly interested in applying their innovative techniques to dyslexia research. 40+ international contributors from multiple disciplines present groundbreaking research on:
  • neurolinguistic and neurophysiological precursors of dyslexia
  • new techniques and technologies—ranging from molecular genetics, to neuroimaging, to cognitive neuroscience
  • genetic influences on reading and reading disability
  • the magnocellular theory of dyslexia
  • anatomical risk factors for reading and language disorders
  • subcortical auditory function and how it contributes to variance in reading ability
  • cortical phenotypes associated with developmental dyslexia
  • the impact of atypical auditory processing in infancy on later language and reading skills
  • the interplay among environment, brain, and behavior while children are developing reading skills
  • phonological processing difficulties and their effect on later literacy outcomes
  • the latest techniques in pediatric neuroimaging
  • and more

Each of the book's four sections has a helpful integrative introduction. And to help readers shape the course of future dyslexia studies, a concluding chapter distills the key themes discussed at the symposium and examines specific recommendations for further research on the genetics, neurobiology, and behavior of dyslexia.

An important volume that will be cited and quoted in the literature for years to come, this book sheds new light on the precursors and early indicators of dyslexia—and will provide a strong foundation for tomorrow's innovative interventions.

With contributions by well-known experts from the dyslexia field, including

  • Nadine Gaab
  • John Stein
  • Elena L. Grigorenko
  • Fumiko Hoeft
  • Cyril Pernet
  • Cecilia Marino
  • Ben Maassen
  • Nina Kraus, and
  • Bruce D. McCandliss

PLUS additional experts from related fields, including

  • neuroimaging (P. Ellen Grant)
  • molecular genetics and anatomy (Richard S. Nowakowski and Joseph J. LoTurco)
  • animal models (Glenn D. Rosen)
  • and more!


Review by: Albert Galaburda, Emily Fisher Landau Professor of Neurology and Neuroscience, Harvard Medical School, Chief, Division of Cognitive Neurology Beth Israel Deaconess Medical Center
"This is the book to read and keep on your shelf if you want to know what is happening in dyslexia research today."
Review by: Annette Karmiloff-Smith, Birkbeck Centre for Brain & Cognitive Development, University of London
"Fundamentally developmental and multidisciplinary in perspective, the book is a must for all those interested in how low-level deficits in at-risk pre-dyslexic infants can impact over time on higher-level reading outcomes."

Table of Contents

About the Editors
About the Contributors
William Baker, April Benasich, & R. Holly Fitch

I. Brain Development, Genes, and Behavior Phenotypes

R. Holly Fitch

  1. Overview of Early Brain Development: Linking Genetics to Brain Structure
    Richard S. Nowakowski & Nancy L. Hayes
  2. Loss of the Dyslexia Susceptibility Gene DCDC Increases Synaptic Connectivity in the Mouse Neocortex
    Joseph J. LoTurco, Aarti Tarker, & Alicia Che
  3. The Magnocellular Theory of Dyslexia
    John Stein
  4. Investigation of Candidate Genes in Families with Dyslexia
    Cecilia Marino, Sara Mascheretti, Andrea Facoetti, & Massimo Molteni
  5. What Educators Should Know About the State of Research on Genetic Influences on Reading and Reading Disability
    Elena L. Grigorenko

II. Potential Early Precursors of Specific Language Impairment and Dyslexia

April A. Benasich

  1. Biological Factors Contributing to Reading Ability: Subcortical Auditory Function
    Bharath Chandrasekaran & Nina Kraus
  2. Timing, Information Processing, and Efficacy: Early Factors that Impact Childhood Language Trajectories
    April A. Benasich & Naseem Choudhury
  3. Neurolinguistic and Neurophysiological Precursors of Dyslexia: Selective Studies from the Dutch Dyslexia Programme
    Ben Maassen, Aryan van der Leij, Natasha Maurits, & Frans Zwarts
  4. Phonology and Literacy: Follow-Up Results of the Utrecht Dyslexia and Specific Language Development Project
    Elise de Bree, Margaret Snowling, Ellen Gerrits, Petra van Alphen, Aryan van der Leij, & Frank Wijnen

III. Potential Neurobehavioral Markers and Biological Mechanisms of Specific Language Impairment and Dyslexia

R. Holly Fitch

  1. Cortical Phenotypes Associated with Developmental Dyslexia: Reverse and Forward Genetic Approaches Using Animal Models
    Glenn D. Rosen
  2. Using Animal Models to Dissociate Genetic, Neural, and Behavioral Contributors to Language Disability
    R. Holly Fitch & Caitlin E. Szalkowski
  3. Prediction of Children's Reading Skills: Understanding the Interplay Among Environment, Brain, and Behavior
    Jessica M. Black & Fumiko Hoeft
  4. A Multifactorial Approach to Dyslexia
    Cyril R. Pernet & Jean-Franois Dmonet

IV. Developmental Neuroimaging: Identification, Intervention, and Remediation

April A. Benasich

  1. Evolution of Pediatric Neuroimaging and Application of Cutting-Edge Techniques
    P. Ellen Grant
  2. Anatomical Risk Factors for Reading Comprehension
    Christiana M. Leonard
  3. Windows into Receptive Processing
    Elena Plante
  4. Neural Correlates of Reading-Related Processes Examined with fMRI Before Reading Onset and After Language/Reading Remediation
    Nora M. Raschle, Michelle Lee, Patrice L. Stering, Jennifer Zuk, & Nadine Gaab
  5. Transcending Gaps Among Disciplines in Neurodevelopmental Disorders: From Brain Volumetrics to Collaborative Multisystem Assessment
    Martha R. Herbert
  6. Integration of Left-Lateralized Neural Systems Supporting Skilled Reading
    Bruce D. McCandliss & Yuliya Yoncheva

Conclusion/Next Steps: Critical Research, Directions, and Priorities
Peggy McCardle & Brett Miller


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