Developmental Dyslexia: Early Precursors, Neurobehavioral Markers, and Biological Substrates

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Description

Understanding the precursors and early indicators of dyslexia is key to early identification and effective intervention. Now there's a single research volume that brings together the very latest knowledge on the earliest stages of dyslexia and the diverse genetic, neurobiological, and cognitive factors that may contribute to it. Based on findings first reported at the Dyslexia Foundation's 12th Extraordinary Brain Symposium, this landmark volume collects cutting-edge dyslexia research from the worlds foremost experts on this complex disorder, as well as insights from experts newly interested in applying their innovative techniques to dyslexia research. 40+ international contributors from multiple disciplines present groundbreaking research on:

• neurolinguistic and neurophysiological precursors of dyslexia
• new techniques and technologies—ranging from molecular genetics, to neuroimaging, to cognitive neuroscience
• genetic influences on reading and reading disability
• the magnocellular theory of dyslexia
• anatomical risk factors for reading and language disorders
• subcortical auditory function and how it contributes to variance in reading ability
• cortical phenotypes associated with developmental dyslexia
• the impact of atypical auditory processing in infancy on later language and reading skills
• the interplay among environment, brain, and behavior while children are developing reading skills
• phonological processing difficulties and their effect on later literacy outcomes
• the latest techniques in pediatric neuroimaging
• and more

Each of the book's four sections has a helpful integrative introduction. And to help readers shape the course of future dyslexia studies, a concluding chapter distills the key themes discussed at the symposium and examines specific recommendations for further research on the genetics, neurobiology, and behavior of dyslexia.

An important volume that will be cited and quoted in the literature for years to come, this book sheds new light on the precursors and early indicators of dyslexia—and will provide a strong foundation for tomorrow's innovative interventions.

With contributions by well-known experts from the dyslexia field, including

• Nadine Gaab
• John Stein
• Elena L. Grigorenko
• Fumiko Hoeft
• Cyril Pernet
• Cecilia Marino
• Ben Maassen
• Nina Kraus, and
• Bruce D. McCandliss

PLUS additional experts from related fields, including

• neuroimaging (P. Ellen Grant)
• molecular genetics and anatomy (Richard S. Nowakowski and Joseph J. LoTurco)
• animal models (Glenn D. Rosen)
• and more!

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Reviews

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Table of Contents

About the Editors
About the Contributors
Preface
William Baker, April Benasich, & R. Holly Fitch
Acknowledgments

I. Brain Development, Genes, and Behavior Phenotypes

Introduction
R. Holly Fitch

1. Overview of Early Brain Development: Linking Genetics to Brain Structure
   Richard S. Nowakowski & Nancy L. Hayes
2. Loss of the Dyslexia Susceptibility Gene DCDC Increases Synaptic Connectivity in the Mouse Neocortex
   Joseph J. LoTurco, Aarti Tarker, & Alicia Che
3. The Magnocellular Theory of Dyslexia
   John Stein
4. Investigation of Candidate Genes in Families with Dyslexia
   Cecilia Marino, Sara Mascheretti, Andrea Facoetti, & Massimo Molteni
5. What Educators Should Know About the State of Research on Genetic Influences on Reading and Reading Disability
   Elena L. Grigorenko

II. Potential Early Precursors of Specific Language Impairment and Dyslexia

Introduction
April A. Benasich

6. Biological Factors Contributing to Reading Ability: Subcortical Auditory Function
   Bharath Chandrasekaran & Nina Kraus
7. Timing, Information Processing, and Efficacy: Early Factors that Impact Childhood Language Trajectories
   April A. Benasich & Naseem Choudhury
8. Neurolinguistic and Neurophysiological Precursors of Dyslexia: Selective Studies from the Dutch Dyslexia Programme
   Ben Maassen, Aryan van der Leij, Natasha Maurits, & Frans Zwarts
9. Phonology and Literacy: Follow-Up Results of the Utrecht Dyslexia and Specific Language Development Project
   Elise de Bree, Margaret Snowling, Ellen Gerrits, Petra van Alphen, Aryan van der Leij, & Frank Wijnen

III. Potential Neurobehavioral Markers and Biological Mechanisms of Specific Language Impairment and Dyslexia

Introduction
R. Holly Fitch

10. Cortical Phenotypes Associated with Developmental Dyslexia: Reverse and Forward Genetic Approaches Using Animal Models
    Glenn D. Rosen
11. Using Animal Models to Dissociate Genetic, Neural, and Behavioral Contributors to Language Disability
    R. Holly Fitch & Caitlin E. Szalkowski
12. Prediction of Children's Reading Skills: Understanding the Interplay Among Environment, Brain, and Behavior
    Jessica M. Black & Fumiko Hoeft
13. A Multifactorial Approach to Dyslexia
    Cyril R. Pernet & Jean-Franois Dmonet

IV. Developmental Neuroimaging: Identification, Intervention, and Remediation

Introduction
April A. Benasich

14. Evolution of Pediatric Neuroimaging and Application of Cutting-Edge Techniques
    P. Ellen Grant
15. Anatomical Risk Factors for Reading Comprehension
    Christiana M. Leonard
16. Windows into Receptive Processing
    Elena Plante
17. Neural Correlates of Reading-Related Processes Examined with fMRI Before Reading Onset and After Language/Reading Remediation
    Nora M. Raschle, Michelle Lee, Patrice L. Stering, Jennifer Zuk, & Nadine Gaab
18. Transcending Gaps Among Disciplines in Neurodevelopmental Disorders: From Brain Volumetrics to Collaborative Multisystem Assessment
    Martha R. Herbert
19. Integration of Left-Lateralized Neural Systems Supporting Skilled Reading
    Bruce D. McCandliss & Yuliya Yoncheva

Conclusion/Next Steps: Critical Research, Directions, and Priorities
Peggy McCardle & Brett Miller

Index